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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Incubation of blood platelets with increasing concentrations of … excessive modification in protein amino groups: glucose … ASA competed with each other in the course of nonenzymatic modifications, glycosylation, or acetylation, and their contributions to … for glucose, R2=0.43 for ASA) were dependent upon the concentrations of glucose and ASA.”
Increased protein glycation in diabetes mellitus is associated with decreased aspirin-mediated protein acetylation and reduced sensitivity of blood platelets to aspirin“ Aspirin administration was also found to modulate crucial parameters of tumor microenvironment, including contents of glucose , lactate and cell growth regulatory cytokines, in a gender specific manner.”
“ ASA alone does not affect the binding affinity of α2-antiplasmin to fibrin, but partly reverses the effect introduced by the incubation with 50 mmol/l glucose.”
“ Abstract Glucose has been found to impair the inhibition of platelets with aspirin and alter the basal activity of nitric oxide synthase (NOS) in platelets.”
“On the other hand, short-term exposure of platelets to glucose also attenuates the effect of aspirin on platelets.”
“In … of glucose, … aspirin and its influence on nitric oxide production were diminished (IC50 54 microM with 5 mM glucose vs.556 microM with 16.6 mM … on the platelet-subendothelium interaction was reduced (10.5% platelet occupancy with 5 mM glucose vs.23% with 16.6 mM glucose).”
“ Acetylsalicylic acid enhances the b-cell sensitivity to glucose as well as impairing glucose metabolism of insulin sensitive tissues [4].”
“ Aspirin treatment also resulted in a approximately 20% reduction in basal rates of hepatic glucose production and a approximately 20% improvement in insulin-stimulated peripheral glucose uptake under matched plasma insulin concentrations during the clamp.”
“Pretreatment of … membranes with aspirin or acetyl chloride diminished the extent of glycation … occurred when platelet membranes were subsequently incubated with glucose , but membrane fluidity was reduced even in the absence of glucose; subsequent incubation with glucose caused no further reduction in membrane fluidity.(ABSTRACT TRUNCATED AT 250 WORDS)”
“ Acetylsalicylic acid interfered in six assays (for glucose , uric acid, protein and cholesterol).”
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