Possible Interaction: Aspirin and Ginseng

“Similarly, case reports have demonstrated that ginkgo may potentiate bleeding when combined with warfarin or aspirin , increases blood pressure when combined with thiazide diuretics, and has even led to a coma when combined with trazodone, a serotonin antagonist and reuptake inhibitor used to treat depression.”

“Potential risks of bleeding due to the use of Ginkgo biloba, garlic or ginseng with aspirin or warfarin was the most reported herb–drug interaction.”

“Most (379) involved a risk of bleeding due to use of ginkgo, garlic, or ginseng together with aspirin , warfarin, ticlopidine, or pentoxifylline.”

“Two of the commonest prescribed medicines, aspirin and warfarin can cause such spontaneous bleeding when taken in conjunction with Ginkgo biloba, ginseng (Panax ginseng), feverfew, ginger and garlic, all of which have some anticoagulant and/or antiplatelet activity.”

“Compared with the aspirin group, area under the curve (AUC 0-t) and maximum concentration of salicylic acid in rats of … (P<0.01), while clearance rate (CLz/F) decreased clearly (P<0.05).Conclusion The in vivo study showed that red ginseng extract can … aspirin , and delay … aspirin.”

“Also, the use of ASA as an elicitor resulted in the inhibition of biomass growth and an increase in total ginseng saponin content at every elicitor dosage (0.1 to 1.0 mM) by about 1.1 times.”