Possible Interaction: Aspirin and Folic Acid

“All had antithrombotic prophylaxis with low-dose aspirin and/or low-molecular-weight heparin, supplemented with folic acid.”

“However, Figure 2 … indicates that the aspirin placebo subgroup, but not the 2 active aspirin subgroups (81 mg/d and …), seemed to be associated with an increased frequency of advanced lesions in the folic acid group during the first follow-up interval, … did not appear to reach statistical significance.”

“We suggest that the authors assess whether this possible interaction between aspirin and folic acid intake exists in the second follow-up interval, because it is possible that a residual effect of 3 years of aspirin intake would persist for another 3 to 5 years.”

“The antagonistic effects of folic acid to aspirin on the development of rat yolk sac and embryos were studied during early organogenesis by using whole embryo culture technique and electron microscopy.”

“The results suggested that the protection of yolk sac would be related to the antagonism of folic acid to aspirin.”

“ Acetylsalicylic acid (1 mM), which is known to suppress the formation of 3‐OH‐FA from exogenous polyenoic fatty acids, inhibited the occurrence of immunoreactive material as well as the sexual phase of the life cycle suggesting a prominent regulatory role of 3‐OH‐FA for the latter.”

“However, when the macrobroth dilution method was used, the growth of LcS was inhibited by ASA , SAS, acetaminophen, and sodium ibuprofen.”