Possible Interaction: Aspirin and Fish Oils

“ FO ingestion reduced all lysophosphatidic acid (LPA) concentrations, while EPA (20:5n-3) and DHA (22:6n-3) lysophosphatidylcholine (LPC) concentrations significantly increased after FO alone and in combination with aspirin.”

“The possible modulating effects of co-administration of aspirin and fish oil in subjects with diabetes are poorly characterized.”

“A combination of stable fish oil and aspirin thus improves the eicosanoid pattern more than aspirin alone.”

“Leukotriene B(4)was increased by 19% (P<0.05) after aspirin, and decreased by 69% (P<0.05) after fish oil + aspirin.”

“Serum thromboxane A(2)was decreased by 40% (P<0.05) after aspirin alone, but by 62% (P<0.01) after fish oil + aspirin.”

“A significant decrease in binding was found in those who took aspirin in combination with fish oil (P = 0.03).”

“This study found that the combined effect of low-dose aspirin and fish oil causes a significant decrease in platelet angiotensin II binding not caused by either compound taken alone.”

“ResultsTo date, there is good emerging evidence that dietary supplementation with fish oil may be of some benefit and this is enhanced if combined with aspirin.”

“The n-3-enriched diets, especially the fish oil diets, reduced the stimulatory effect of in vitro added acetylsalicylic acid (aspirin) on lymphocyte proliferation.”

“It was postulated that elevated air pollutant concentrations would be associated with increases in measures of platelet function and that responses would be blunted when taking aspirin and/or fish oil.”

“Specifically, we wanted to determine whether the ASA-induced reduction in prostacyclin production is due to inhibition of endothelial cell cyclooxygenase or to reduced endoperoxide shift from platelets and whether ASA negates the potentially beneficial effects of fish oil on the eicosanoid profile.”

“Fish oil alone raised bleeding times only slightly (9%; N.S.), but aspirin plus fish oil raised them by 78% (p less than 0.01).”

“Since fish oil and aspirin had synergistic effects on bleeding times, but not on platelet aggregation, these two substances appear to affect hemostasis by different mechanisms.”

“Following a 14-day washout, six dogs received fish oil, and nine dogs received combination therapy of aspirin plus fish oil ; haemostatic testing was performed before and at 7 and 28 days after treatment initiation.”

“The combination of aspirin plus fish oil therapy caused a significantly greater inhibition of adenosine diphosphate and collagen-induced whole blood aggregometry compared to aspirin alone.”