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Last Updated: 2 years ago

Possible Interaction: Aspirin and Epinephrine





Research Papers that Mention the Interaction

At that time ASA had blocked the secondary phase of adrenaline-and ADP-induced platelet aggregation.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
In 50% of healthy blood donors the intake of 75 mg ASA a day resulted in the prolongation of PFA-100 collagen/epinephrine closure time ( CEPI = (relevant to reduced platelet reactivity) of over 150 s, whereas 75% donors responded to 150 mg ASA-.
Otherwise, the daily dose of 150 mg ASA resulted in a prolonged CEPI merely in 23% of in IHD patients.
Polskie Archiwum Medycyny Wewnetrznej  •  2000  |  View Paper
Arachidonic acid and epinephrine promoted a stronger platelet aggregation in aspirin nonresponders than in aspirin responders while taking 300 mg/day aspirin.
Journal of the Neurological Sciences  •  1999  |  View Paper
Meanwhile, aspirin significantly reduced platelet aggregation induced by collagen (61.4%) and epinephrine (21.9%) but not ADP-induced aggregation.
Pharmacological research  •  1997  |  View Paper
When adrenaline was used as the aggregating agent, the cyclo-oxygenase pathway was recruited in the increased reactivity seen in the third trimester of normal pregnancy, and was sensitive to inhibition by low dose aspirin.
British journal of obstetrics and gynaecology  •  1992  |  View Paper
Aspirin 50 mg/day suppressed arachidonate-induced platelet aggregation and secondary phase aggregation after ADP and adrenaline.
Thrombosis and haemostasis  •  1985  |  View Paper
Since the ocular hypotensive effect of topically applied epinephrine is inhibited by indomethacin, a cyclo-oxygenase inhibitor, these results suggest that this … mediated by the endogenous production of prostaglandins, or other cyclo-oxygenase products, and that the intraocular pressure of glaucoma patients undergoing epinephrine therapy may increase … or aspirin ….
American journal of ophthalmology  •  1985  |  View Paper
Compared to placebo, aspirin induced a persistent increase in bleeding time (% difference 45.6 +/- 21.4, mean +/- SD) and a decrease in platelet aggregation by ADP, epinephrine , collagen and arachidonic acid.
European heart journal  •  1985  |  View Paper
Since the platelets of patients with familial hypercholesterolaemia (FH) are hyperaggregable, the inhibitory effect of low-dose aspirin on platelet aggregation in response to adenosine diphosphate, collagen, adrenaline and arachidonic acid was tested in 9 young adult patients with FH and compared with that in 9 normal subjects.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde  •  1983  |  View Paper
MDA formation and platelet aggregation induced by adenosine disphosphate (ADP), collagen, and adrenaline were inhibited by doses of aspirin smaller than those inhibiting prostacyclin production.
The Lancet  •  1979  |  View Paper
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