Possible Interaction: Aspirin and Carrageenan

“The injection of both hypoxen and acetylsalicylic acid before the injection of carrageenan produced a strong anti-inflammatory effect, which was manifested by a reliable decrease in all monitored signs of inflammation.”

“The results showed that oral administration of nanoemulsion and nano multiple emulsion containing aspirin (60 mg/kg) significantly reduced paw edema induced by λ-carrageenan injection.”

“Remarkably, hyperalgesia evoked by Bjv or carrageenan was completely blocked in animals treated with ARPI or busulfan, or pre‐treated with aspirin or clopidogrel.”

“Our results stressed on the role of IL-1beta and NO in the acute inflammation and suggested that the dose of carrageenan is the major determinant in the response to ASA.”

“Piroxicam and aspirin significantly inhibited inflammatory cell influx, exudate and prostaglandin E2 formation, 6 h after carrageenin injection.”

“Both the two doses of aspirin and acetaminophen greatly reduced the inflammatory signs associated with the intraplantar injection of carrageenin.”

“Verapamil in minimum therapeutic equivalent dose, failed to show anti-inflammatory activity as did sub-anti-inflammatory dose of aspirin (54 mg/kg) however, when combined with sub-antiinflammatory dose of aspirin , significant (P < 0.001) inhibition of carrageenan and cotton pellet induced inflammation was observed.”

“Prednisolone, indomethacin, phenylbutazone and aspirin inhibited the carrageenin , formalin-induced edema, cotton pellet granuloma and adjuvant arthritis apparently, but flufenamic acid showed no inhibition on the carrageenin and formalin-induced edema.”

“During the summer months, aspirin was relatively ineffective in rats in suppressing leucocyte migration both into the pleural space inflamed by carrageenan and into inert sponges implanted subcutaneously.”

“ Aspirin exhibited equal suppression of carrageenan oedema in both normal and EFAD rats, despite the fact that, in the latter, prostaglandins are of negligible importance.”