Possible Interaction: Aspirin and Calcium Supplement

“Compared with levels in untreated patients, platelet levels of baseline Ca <] decreased only in patients taking aspirin (Table 1).”

“In rabbit, mouse, and rat plasma, carboxylesterase (CES) was determined to be the enzyme responsible for aspirin hydrolysis, and in mouse and rat plasma, … BChE. Interestingly, divalent cations affected the plasma activity by enhancing or inhibiting the hydrolase activity of plasma BChE. The addition of 2 mM calcium … aspirin ….”

“Three murine monoclonal antibodies (anti-CD9: ALB6, anti-CD41: VI-PL3 and PL2-49/GPIIb - final concentration: … micrograms/mL) are shown to elicit after a lag time aggregation of washed platelets and a calcium signal (as detected by light emitted by loaded …), which is only partially inhibited by aspirin.”

“Moreover, ASA treatment induced significantly upregulation of intracellular levels of glucose (iGlu), and free calcium ions (ifCa2+), and, covertly, significantly downregulation of total cellular cholesterol content (tccCHOL).”

“Furthermore, during … of aspirin in … of calcium ions , we demonstrated the existence of two additional binding sites for calcium, with Km-values of 1.8 and 5.9 mM. … binding sites exhibited much lower affinities than the EF-hand motif, previously identified as a high-affinity calcium-binding site.”

“It is established that in the given test acetylsalicylic acid inhibits thrombin-induced increasing of cytoplasmic Ca at 0.125-5.0 mk/mol concentrations.”

“The combined supplementation of aspirin and calcium starting at 20-27 weeks of gestation produced a nonsignificant decrease in the incidence of superimposed preeclampsia and fetal growth restriction in hypertensive women with abnormal uterine artery Doppler.”

“The rate of superimposed preeclampsia was 28.6% lower among women receiving aspirin plus calcium than in the placebo group (52.2 vs 73.1%, respectively, P=0.112).”

“Consumption of calcium supplement plus low-dose aspirin resulted in a significant difference serum hs-CRP levels as compared to the placebo (102.87 vs. 3227.75 ng mL(-1), p = 0.01).”

“…,consumption calcium supplement … aspirin during pregnancy for 9 weeks in pregnant women at risk for pre-eclampsia resulted in a significant difference serum hs-CRP and increased … plasma TAC and total GSH as compared to the placebo group, but could not affect serum insulin levels and HOMA-IR score.”

“Conclusions CACS >400 was associated with a higher likelihood of initiation and continuation of LLM, BPLM, and ASA.”

“Approximately 45% decrease in cell viability for aspirin (15 mM) and calcium (30 mM) mixtures was observed in HT-29 cell lines, compared to approximately 55% decrease by the same combination in SW-480 cell lines.”