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Last Updated: 2 years ago

Possible Interaction: Aspirin and Caffeine

drug:

Aspirin

supplement:

Caffeine

Research Papers that Mention the Interaction

Recent studies have demonstrated that caffeine acts as an analgesic adjuvant when combined with acetaminophen, aspirin , or their mixture.
Clinical pharmacology and therapeutics  •  1991  |  View Paper
This study therefore demonstrated that the addition of caffeine to aspirin , in a dose commonly employed in over-the-counter drugs, has significant beneficial consequences with respect to mood and performance. (
We observed that caffeine (64 mg), when added to aspirin (800 mg), significantly improves vigilance performance and increases self-reported efficiency when compared with either placebo or aspirin alone.
Journal of clinical psychopharmacology  •  1987  |  View Paper
chronic dosing with a low dose (50 mg/kg) did not increase N-hydroxyphenacetin excretion, but a marked increase occurred on concomitant administration of aspirin and caffeine.
Xenobiotica; the fate of foreign compounds in biological systems  •  1985  |  View Paper
Compared with analgesic medication alone, combinations of caffeine with analgesic medications, including acetaminophen, acetylsalicylic acid , and ibuprofen, showed significantly improved efficacy in the treatment of patients with TTH or migraine, with favorable tolerability in the vast majority of patients.
The Journal of Headache and Pain  •  2017  |  View Paper
There is evidence that caffeine alone or in association with Acetaminophen, Ibuprofen, or Aspirin can increase their analgesic effects.
Journal of medicine and life  •  2017  |  View Paper
In a recent Cochrane review based on 19 … with a total of 7238 patients, caffeine enhanced the efficacy of paracetamol, ibuprofen or aspirin with a number needed to treat (NNT) of about 16, comparable to the effect of doubling the dose of the primary analgesic, reported by other authors.
MMW Fortschritte der Medizin  •  2013  |  View Paper
Objective: To assess whether codeine and caffeine enhance the analgesic effect of aspirin in postoperative pain.
Journal of clinical pharmacy and therapeutics  •  1997  |  View Paper
Hypocitraturia, hypoaciduria, hypomagnesiuria, systemic acidosis and hypercalciuria favour the production of nephrocalcinosis and kidney stones,' which … association with hereditary renal t.ubular acidosis' and with analgesic nephropathy in man.s " Combination of aspirin … caffeine , however, showed a protective interaction by increasing the … citrate, hydrogen ions, sodium, potassium and magnesium.
The Medical journal of Australia  •  1971  |  View Paper
Hypocitraturia, hypoaciduria, hypomagnesiuria, systemic acidosis and hypercalciuria favour the production of nephrocalcinosis and kidney stones,' which … association with hereditary renal t.ubular acidosis' and with analgesic nephropathy in man.s " Combination of aspirin … caffeine , however, showed a protective interaction by increasing the … citrate, hydrogen ions, sodium, potassium and magnesium.
The Medical journal of Australia  •  1971  |  View Paper
A fixed dose of CAF was able to improve the anti‐nociceptive, but not the anti‐inflammatory, effects of ASA.
European journal of pain  •  2008  |  View Paper
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