Possible Interaction: Aspirin and Caffeine

“Recent studies have demonstrated that caffeine acts as an analgesic adjuvant when combined with acetaminophen, aspirin , or their mixture.”

“This study therefore demonstrated that the addition of caffeine to aspirin , in a dose commonly employed in over-the-counter drugs, has significant beneficial consequences with respect to mood and performance. (”

“We observed that caffeine (64 mg), when added to aspirin (800 mg), significantly improves vigilance performance and increases self-reported efficiency when compared with either placebo or aspirin alone.”

“chronic dosing with a low dose (50 mg/kg) did not increase N-hydroxyphenacetin excretion, but a marked increase occurred on concomitant administration of aspirin and caffeine.”

“Compared with analgesic medication alone, combinations of caffeine with analgesic medications, including acetaminophen, acetylsalicylic acid , and ibuprofen, showed significantly improved efficacy in the treatment of patients with TTH or migraine, with favorable tolerability in the vast majority of patients.”

“There is evidence that caffeine alone or in association with Acetaminophen, Ibuprofen, or Aspirin can increase their analgesic effects.”

“In a recent Cochrane review based on 19 … with a total of 7238 patients, caffeine enhanced the efficacy of paracetamol, ibuprofen or aspirin with a number needed to treat (NNT) of about 16, comparable to the effect of doubling the dose of the primary analgesic, reported by other authors.”

“Objective: To assess whether codeine and caffeine enhance the analgesic effect of aspirin in postoperative pain.”

“Hypocitraturia, hypoaciduria, hypomagnesiuria, systemic acidosis and hypercalciuria favour the production of nephrocalcinosis and kidney stones,' which … association with hereditary renal t.ubular acidosis' and with analgesic nephropathy in man.s " Combination of aspirin … caffeine , however, showed a protective interaction by increasing the … citrate, hydrogen ions, sodium, potassium and magnesium.”

“Hypocitraturia, hypoaciduria, hypomagnesiuria, systemic acidosis and hypercalciuria favour the production of nephrocalcinosis and kidney stones,' which … association with hereditary renal t.ubular acidosis' and with analgesic nephropathy in man.s " Combination of aspirin … caffeine , however, showed a protective interaction by increasing the … citrate, hydrogen ions, sodium, potassium and magnesium.”

“A fixed dose of CAF was able to improve the anti‐nociceptive, but not the anti‐inflammatory, effects of ASA.”