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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aspirin
supplement:
Arachidonate
Research Papers that Mention the Interaction
“ Aspirin inhibits TXAa-dependent platelet functions by irreversibly acetylating platelet cyclooxygenase, the enzyme which converts arachidonate released from membrane phospholipids into prostaglandin endoperoxides [6].”
Effects of indobufen on platelet thromboxane B2 production in patients with myocardial infarction“ Aspirin inhibited platelet aggregation in response to arachidonate in the presence and in the absence of FAEE.”
“A single dose of oral aspirin in human subjects inhibits the aggregation response of platelets to arachidonate and other agents for approximately one week after ingestion.”
“However, the arachidonate induced coronary relaxation was inhibited by pretreatment with PG synthetase inhibitors, indomethacin, meclofenemate and aspirin.”
“ Aspirin also inhibits thrombin generation (TG) in platelet-rich plasma (PRP) activated by sodium arachidonate ( AA).”
“BACKGROUND Aspirin inhibits cyclooxygenase activity and modifies production of the arachidonate cascade in aspirin-induced asthma.”
“ Aspirin administered in vivo produced a decrease of TG in PRP activated with AA.”
“Only ticlopidine plus ASA significantly inhibited EC 50 of ADP, collagen and arachidonate.”
“Platelet activation induced by a low level of arachidonate (0.1-5 micrograms/ml) was inhibited by aspirin , but activation induced by a high level of arachidonate (10-50 micrograms/ml) was not.”
“Only Aspirin enhanced the formation of lipoxygenase metabolites of radiolabeled arachidonate.”
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