Possible Interaction: Aspartic Acid and Vitamin D

“Abstract Young dogs receiving daily excessive doses of vitamin D 2 and D 3 for a five-month period manifested profound pathologic changes, which included distorted and deformed roots, pathologic calcifications of connective tissues of the paradentium, hypercementosis, pulp stone formation, and advanced paradentosis.”

“In contrast, D 2 supplementation increased 25(OH)D 2 by + 347% (7.0 ± 1.1 nmol·L − 1 to 31.4 ± 2.1 nmol·L − 1 , p < 0.0001), but resulted in a − 42% reduction in 25(OH)D 3 by week 6 (p = 0.001).”

“Results: Linear regression analysis showed that as 25(OH) D level increased by 1 ng/mL, myopic refractive error significantly decreased by 0.01 D (P < 0.001) after adjusting for potential confounders including sex, age, height, education level, economic status, physical activity, and sunlight exposure time.”

“Conclusion High dose cholecalciferol significantly increases 25(OH)vitamin D and 1,25(OH)2vitamin D levels compared to placebo.”

“At 31 D , birds that received VD3 levels of 3,125 and 7,813 IU/kg of feed showed 2.9 folds higher in NaPi-IIb expression compared with those fed lowest level of VD3 at 80 IU/kg of feed.”

“ Vitamin D stimulated both Ca entry and exist from the chorion cells as indicated by the increased accumulated 45Ca in + D embryos.”

“Accordingly the three A-homo analogs of vitamin D 3 were assessed for their ability to inhibit or increase the ICA or BCM responses of D 3 and 1,25-(OH) 2 D 3 .”