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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Aspartic Acid
drug:
Valproic Acid
Research Papers that Mention the Interaction
“Administrations of D ,L-carnitine and albumin reduced VPA hepatotoxicity.”
Evaluation of the cytotoxicity of sodium valproate on primary cultured rat hepatocytes.“At the same time, administration of valproic acid induced a decrease of aspartic acid in the CSF of epileptics.”
“ DPAT or 5-HT injections decreased the duration of electrographically-determined waking, increased the durations of D and induced the emergence of SWS and REMS states indistinguishable from the hippocampal EEG associated with spontaneous sleep, as judged from visual and spectral analysis.”
Serotonergic control of ingestive and post-ingestive behaviors in pigeons (Columba livia): The role of 5-HT1A receptor-mediated central mechanisms“We have previously reported that chronic administration of valproate in developing mice decreased brain aspartic and glutamic acid levels and increased the brain taurine content.”
“When D ,L-carnitine was added with VPA to the medium, the level of ammonia decreased significantly and that of ketone bodies increased.”
“ Valproic acid acutely alters regional brain concentrations of GABA and of aspartic and glutamic acids in vivo, and it potentiates the action of these amino acid neurotransmitters on neurons in vitro.”
“It was found that VPA elicited a substantial (max 21-26%) decrease in E* and a smaller (max 5.9-6.9%) reduction in D of FA independent of the presence of absence of the pituitary gland.”
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