Possible Interaction: Aspartic Acid and Serotonin

“Also in blood platelets frequently used as … cells of the nerve endings the serotonin uptake is inhibited … small concentrations of D 145, 10(-5) to 2X10(-4) M. High concentrations of D 145- greater than …(-3) M, induce the "release-reaction", the simultaneous liberation of serotonin, ATP, and ADP.”

“At the presynaptic side, 5-HT activates 5-hydroxytryptamine (serotonin) receptor 1A (HTR1A), B (HTR1B), and D (HTR1D), which results in an attenuation of the 5-HT exocytosis [2].”

“DPAT or 5-HT injections decreased the duration of electrographically-determined waking, increased the durations of D and induced the emergence of SWS and REMS states indistinguishable from the hippocampal EEG associated with spontaneous sleep, as judged from visual and spectral analysis.”

“Compared with group B, the myocardial contents of AD and 5-HT were decreased significantly in group C and D (P<0.01), while myocardial DA concentration in group D increased significantly (P<0.01).”

“ D ,L-kawain caused a decrease in 5-HT concentrations.”

“It has been reported that D inhibits the bronchoconstriction induced by serotonin (5-HT) but not that by histamine (H) or acetylcholine.”

“Prazosin (70−6 M) affected neither 5-HT-induced … the inhibition by D.ConclusionOur data indicate that D partially blocks the … not only to 5-HT , an effect which would be mediated through a blockade of the 5-…, but also to H or C, probably through inhibition of calmodulin.”

“ResultsWe found that D inhibited the tracheal contractions induced by 5-HT , H or C in a concentration-dependent manner.”

“The inhibiting effect of D was strongest on contractions induced by 5-HT.”

“The results presented … that in D neurons of the snail Helix pomatia L., acetylcholine (…) (10 divided by 100 microM) and serotonin ( 5-HT ) (0.1 divided by 1000 microM) applications reduce both the basal intracellular concentration level ([Ca2+]in) and the amplitudes of calcium transients induced by membrane depolarization.”

“Treatment with phospholipase A2, C or D decreased MAO activities towards 5-hydroxytryptamine (5-HT), beta-phenylethylamine and tyramine similarly, accompanied by great changes in their apparent affinities for MAO, but not by changes in Vmax values.”

“tnot only … levels of 5-HT significantly higher in preparations of nerve endings isolated … telencephalon and diencephalon of pigeons given injections of D ,L-5-HTP, but in vitro studies also show that low concentrations of …-HTP significantly increased the release of radioactive 5-HT from serotonergic nerve endings.”