Possible Interaction: Aspartic Acid and Norepinephrine

“Plasma noradrenaline increased about 100% at 80 D , 160% at 100 D and 310% at 80 DH.”

“ Resting noradrenaline levels were lower in the diabetic ( D ) compared with the control (C) group (D: 1.66, 0.55-3.92 nmol/l vs. C: 2.96, 2.04-4.49 nmol/l, P less than 0.02).”

“The ratio between the spontaneously secreted catecholamines E and NE was increased after treatment with D , indicating a dominant effect on E secreting cells.”

“By choosing an appropriate concentration of D 600 or amrinone, Ca2+ uptake or Ca2+ influx induced by high K+ or NE could be selectively inhibited.”

“These results suggest that verapamil, 600 and prenylamine decrease K+-or Ca2+-induced n oradrenaline release by inhibiting transmembrane Ca2+ influx into the terminal sympathetic nerve fibres.”

“…,neural norepinephrine release … D , Lpropranolol (-38±6% at 0.1 μmol/L, -44 $5% at 1 μmol/L, and -78±3% at 10 μmol/L) or lidocaine (-… inhibit neural norepinephrine release via a Na+ channel-blocking mechanism that is synergistic with changes induced by ischemia, primarily raised extracellular K+.”

“Similarly, norepinephrine inhibited the K(+)-evoked overflow of Glu and Asp , although phenylephrine and isoproterenol showed no effect.”

“ Norepinephrine caused a decrease in D , mean red cell velocity (Vm) and Q within individual microvessels.”

“Microinjections of aspartic acid or chlorpromazine depressed FRA inhibitory action; injection of procaine and noradrenaline potentiated this action.”

“V completely inhibited and D partially inhibited the depolarizing effect of norepinephrine (NE) in VSM of both SHR and WKY.”