Possible Interaction: Aspartic Acid and Nitric Oxide

“At 50µg/mL, the ethyl acetate fraction D ) significantly inhibited IL-1β secretion (-46%) and NO production (-21%), as previously observed for the decoction.”

“The 24h mean level of UA and NO was greater in D than in ND subjects (424 vs. 338 μmol/L and 39.2 vs. 12.7 μM, respectively).”

“Daturmetesides A, C and D moderatelylowered the NO production with IC50 values ranging from 17.05 ± 0.35 to 24.88 ± 0.93 μM.”

“We further demonstrated that l-aspartic acid drives the production of nitrogen oxide that promotes phagocytosis.”

“Moreover, we show that vitamins A, D and omega-3 fatty acids (docosahexaenoic and eicosapentaenoic) at concentrations where they individually had little effect, significantly reduced the secretion of the inflammatory mediator, nitric oxide , when they were combined.”

“ D induced NO production in PAE cells.”

“ D induced NO production to proliferation and/or migration in endothelial cells (EC).”

“Thalassospiramides A and D (2–3) inhibited nitric oxide ( NO ) production in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells, with IC50 values of 16.4 and 4.8 μM, respectively.”

“Similarly, the plasma nitric oxide concentration increased significantly not only in groups C and D but also in group B (P <.05).”

“It was therefore concluded that NO is involved in the regulation of LH, and possibly FSH, secretion and that NO may mediate, at least in part, the stimulatory effects of NMA on LH, and to some extent FSH, release.”

“Superfusion of 4.25% D reverses leukocyte adhesion induced by NO synthesis inhibition.”