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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Aspartic Acid
drug:
Nicotine
Research Papers that Mention the Interaction
“Administration by microdialysis of 10 mM nicotine , resulting in a nicotine concentration of 0.134 μmol/g in the hippocampus, increased the extracellular levels of aspartic acid , glutamic acid, and serine by 26–60%.”
Effect of nicotine on the level of extracellular amino acids in the hippocampus of rat“The inflammatory cytokine tumor necrosis factor alpha (TNFα) is also neuroprotective, however, in the presence of nicotine , neuroprotection against NMDA is abolished.”
“The nicotinic agonists, nicotine , cytisine and epibatidine, elicit dose-dependent increases in spinal release of Asp and Glu.”
“The perfusion of 1 mM nicotine in Ringer's solution increased the extracellular levels of aspartic and glutamic acids by 40-50% in the striatum and had no effect on the levels of serine, glycine, glutamine, taurine or threonine.”
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