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Possible Interaction: Aspartic Acid and Morphine

supplement:

Aspartic Acid

Research Papers that Mention the Interaction

The amount of morphine use at 2, 6 and 24 h was significantly lower in Group D (p<0.006).
Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology  •  2011  |  View Paper
We have previously demonstrated the antagonizing effect of aspartic acid on some effects of morphine and on the development of physical dependence on, and tolerance to, morphine.
Psychopharmacology  •  1979  |  View Paper
Aspartic acid prevented to some extent the appearance of symptoms of physical morphine dependence.
Polish journal of pharmacology and pharmacy  •  1978  |  View Paper
As free amino acids in the brain have a role in the development of … to morphine, and in the mechanism of action of some drugs, the effects of aspartic acid which antagonizes some … dose of morphine were studied during the development of the … and after the withdrawal of morphine.
Aspartic acid prevented the alterations induced by morphine during the development of physical dependence and tolerance.
Arzneimittel-Forschung  •  1977  |  View Paper
Since it has been shown in a previous study that aspartic acid prevents the development of physical dependence on and tolerance to morphine and antagonizes the abstinence syndrom signs, the biochemical bases of that prevention were investigated in the present study.
The relative ineffectiveness of aspartic acid in normalizing some amino acid levels decreased by morphine was discussed and some logical explanations were found.
Psychopharmacology  •  1977  |  View Paper
Both morphine and D-aspartic acid were previously reported to inhibit L-aspartic acid production via blockade of L-asparaginase.
L-Aspartic acid , which was ineffective alone, significantly inhibited the antinociceptive effects of both D-aspartic acid and morphine.
Pharmacology Biochemistry and Behavior  •  1995  |  View Paper
The concomitant administration of L-Asp appeared to significantly antagonize the inhibitory effect of both M and D-Asp.
Agents and actions  •  1987  |  View Paper
While naloxone or L-aspartic acid partly antagonized the suppression of morphine on the lung ACE their combination completely prevented morphine from inhibiting the lung ACE.
Pharmacological research communications  •  1983  |  View Paper
Aspartic acid completely antagonized the effect of morphine.
European journal of pharmacology  •  1979  |  View Paper
In addition aspartic acid can possibly stimulate or inhibit the efflux or influx of morphine in the CNS.
Morphine increased the brain levels of labeled aspartic acid , while the brain content of morphine was decreased.
The antagonistic effect of aspartic acid on some effects of morphine is known.
Psychopharmacology  •  1977  |  View Paper
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