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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Aspartic Acid
drug:
Morphine
Research Papers that Mention the Interaction
“A nalgesic demands and delivered morphine dose were reduced, at any time interval considered, in groups B, C, D , compared with A (P <0.001).”
Intraoperative and Postoperative Analgesia Using Intravenous Opioid, Clonidine and Lignocaine“We have previously demonstrated the antagonizing effect of aspartic acid on some effects of morphine and on the development of physical dependence on, and tolerance to, morphine.”
“Since it has been shown in a previous study that aspartic acid prevents the development of physical dependence on and tolerance to morphine and antagonizes the abstinence syndrom signs, the biochemical bases of that prevention were investigated in the present study.”
“The relative ineffectiveness of aspartic acid in normalizing some amino acid levels decreased by morphine was discussed and some logical explanations were found.”
“As free amino acids in the brain have a role in the development of … to morphine, and in the mechanism of action of some drugs, the effects of aspartic acid which antagonizes some … dose of morphine were studied during the development of the … and after the withdrawal of morphine.”
“ Aspartic acid prevented the alterations induced by morphine during the development of physical dependence and tolerance.”
“ Morphine induced dose-dependent antinociception both in ND and D rats.”
Peripheral participation of cholecystokinin in the morphine-induced peripheral antinociceptive effect in non-diabetic and diabetic rats“In addition aspartic acid can possibly stimulate or inhibit the efflux or influx of morphine in the CNS.”
“ Morphine increased the brain levels of labeled aspartic acid , while the brain content of morphine was decreased.”
“The antagonistic effect of aspartic acid on some effects of morphine is known.”
“Both morphine and D-aspartic acid were previously reported to inhibit L-aspartic acid production via blockade of L-asparaginase.”
“ L-Aspartic acid , which was ineffective alone, significantly inhibited the antinociceptive effects of both D-aspartic acid and morphine.”
“While naloxone or L-aspartic acid partly antagonized the suppression of morphine on the lung ACE their combination completely prevented morphine from inhibiting the lung ACE.”
“ Aspartic acid completely antagonized the effect of morphine.”
“Abstract The decrease in spontaneous motor activity and the increase in analgesic threshold by morphine in rats were antagonized by aspartic acid.”
“The lethal dose of morphine in rats was increased more than two-fold by aspartic acid.”
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