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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Aspartic Acid and Methotrexate

Research Papers that Mention the Interaction

The sequential administration of MTX and D results in significant toxicity without any evidence of a clinical benefit.
European journal of cancer  •  2002  |  View Paper
Our results showed that MTX administration significantly increased ALT, ASP , and ALP levels.
Human & experimental toxicology  •  2013  |  View Paper
Our results showed that MTX administration significantly increased ALP, ASP , ALT, MDA, NO, TNF-α, and IL-1β levels and significantly decreased antioxidant factors such as GSH, CAT, GPx, and SOD.
Naunyn-Schmiedeberg's archives of pharmacology  •  2020  |  View Paper
Enzymic cleavage of 4-amino-N10-methylpteroylglutamic acid (methotrexate) was strongly inhibited by the product l-glutamic acid, and to a lesser extent by l-aspartic acid , while d-glutamic acid was ineffective.
The Journal of biological chemistry  •  1971  |  View Paper