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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Aspartic Acid
drug:
Methotrexate
Research Papers that Mention the Interaction
“The sequential administration of MTX and D results in significant toxicity without any evidence of a clinical benefit.”
Phase I pharmacokinetic and sequence finding study of the combination of docetaxel and methotrexate in patients with solid tumours.“Our results showed that MTX administration significantly increased ALT, ASP , and ALP levels.”
Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation“Our results showed that MTX administration significantly increased ALP, ASP , ALT, MDA, NO, TNF-α, and IL-1β levels and significantly decreased antioxidant factors such as GSH, CAT, GPx, and SOD.”
Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity.“Enzymic cleavage of 4-amino-N10-methylpteroylglutamic acid (methotrexate) was strongly inhibited by the product l-glutamic acid, and to a lesser extent by l-aspartic acid , while d-glutamic acid was ineffective.”
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