Possible Interaction: Aspartic Acid and Lysine

“In bifunctional DNA glycosylases, the conserved Asp is thought to deprotonate a conserved Lys , forming an amine nucleophile.”

“The conservative substitutions of lysine for arginine, alanine for glycine, or glutamic acid for aspartic acid each resulted in abrogation of the cell attachment-promoting activity characteristic of the natural sequence.”

“In long-lived lens proteins, several sites of cross-linking were found to involve the addition of Lys to Asp or Asn residues.”

“Extractions of Asp , Glu, Ser, Asn, Gly, Gln, Tau, His, Cit, Thr, Pro, Tyr, Val, cystine, Ile, Leu, Trp, Orn, and Lys also were correlated with arteriovenous differences of Met.”

“Conversion of Asp‐49 to either Glu or Lys strongly reduces the binding of Ca2+ ions, in particular for the lysine mutant , but the affinity for substrate analogues is hardly affected.”

“The placing of aspartic acid and histidine residues at interacting positions with lysine modulates the steps involved in early peptide glycation (reversible Schiff base formation and its subsequent irreversible conversion to a ketoamine product, the Amadori rearrangement).”

“On the other hand, canavanine (45% of maximum activity) and lysine (13%) stimulated the incorporation of aspartic acid , whereas aspartic acid β-methyl ester (53%) and asparagine (9%) stimulated the incorporation of arginine.”

“Based on an analysis of a set of constructs containing pairs of positively charged Lys and negatively charged … various positions in the model helix, we show that the helix is located deeper in the membrane when Lys … Asp are placed one helical turn apart … spacings of the two residues.”

“The amino acid sequence of these peptides is similar to the local sequence … the labile Asn-67 in RNAse A. The experimental data show that Lys influences both the deamidation rate and the relative … of the two reaction products, i.e., the aspartic acid and beta-aspartic … containing peptide.”

“Either aspartic acid or glutamic acid further enhanced LT synthesis in the presence of methionine and lysine , with aspartic acid being more stimulatory for porcine strains and glutamic acid more stimulatory for human strains.”