“As a result, in the presence of 7‐chlorokynurenic acid , responses to NMDA showed strong desensitization, even in the presence of 3 microM‐glycine.”
“Under these conditions, 7‐chlorokynurenic acid produced a concentration‐dependent block of both the initial and equilibrium response to NMDA , with a 4‐fold greater sensitivity for block of the steady‐state current (IC50 = 2.25 microM) than for block of the peak current (IC50 = 8.96 microM).”