Possible Interaction: Aspartic Acid and Isoproterenol

“Rather, ISO markedly reduced liver injury and improved survival of APAP-treated mice (Fig. 3C, D).”

“ Isoprenaline produced a significant hyperopic shift in TA of 0.47 D over 22 min but this was not accompanied by a significant change in standard deviation of the TA distribution.”

“The activity of serum creatine kinase-MB and the levels of serum troponins T and I and the activities of serum and heart lysosomal enzymes (β-glucuronidase, β-N-acetylglucosaminidase, β-galactosidase, cathepsin-B and D ) were increased significantly (P<0.05) in isoproterenol induced cardio toxic rats.”

“It was found that isoproterenol (10(-5) M) enhanced the diffusion coefficient ( D ) from 4 +/- 0.63 X 10(-7) cm2/s (control) to 2.4 +/- 0.66 X 10(-6) cm2/s.”

“The beta adrenoceptor agonist isoprenaline itself did not effect the T4 to T3 conversion but considerably opposed the inhibitory effect of D ,L-4-OH-propranolol but not of D,L-propranolol.”

“Only at a stimulation frequency of 2 Hz, high concentrations of D 600 (3 X 10(-7)M) and papaverine(3 X 10(-5)M) reduced the response caused by isoprenaline.”

“The inotropic response to isoprenaline appeared to be by far more resistant to the depressive actions of D 600 and papaverine than the baseline contractile function.”