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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Aspartic Acid
drug:
Isoflurophate
Research Papers that Mention the Interaction
“Wild-type human butyrylcholinesterase (BuChE) and Glu-197 ->Asp and Asp-70-->Gly mutants (E197D and D70G respectively) were inhibited by di-isopropyl phosphorofluoridate under standard conditions of pH, temperature and pressure.”
Hydration change during the aging of phosphorylated human butyrylcholinesterase: importance of residues aspartate-70 and glutamate-197 in the water network as probed by hydrostatic and osmotic pressures.“Both the enzymatic and hemolytic activity of D were irreversibly inhibited by treatment with 10 mM DFP as well as by reduction and alkylation.”
“ D is also inhibited by diisopropyl-fluorophosphate and by penylmethyl-sulfonyl-flouride.”
“The structure of the first enzyme:inhibitor covalent adduct of D with diisopropyl fluorophosphate (DIP:D) to a resolution of 2.4 A is described.”
Structure of diisopropyl fluorophosphate-inhibited factor D.
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