Possible Interaction: Aspartic Acid and Insulin

“Both K and D correlated well with the charge properties of the insulin and membrane: when the insulin and membrane carried opposite net charge, the partition coefficient showed relatively larger values, while the effective diffusion coefficient was reduced.”

“Cells preincubated with microfilament … A, B, and D (10 mug/ml), … binding of insulin (30%) and human growth hormone (60%) under steady state conditions, which was not reversed by removing the cytochalasins … the medium and was due entirely to a reduced number of receptor sites on the cell surfact.”

“The maximal antilipolytic responses to insulin were increased in F (27%) and D (29%) when compared to S (16%), (p < 0.05).”

“Luteal cells from Groups C and D rats responded in vitro to insulin by increasing their PDE activity (% of stimulus of specific activity: C = 75%, D = 110%).”

“Intravenous administration of a single 2 IU/kg dose of insulin to D rats at time zero or 4 h after the administration of FD-70 resulted in an increase in some and no change in other animals in their rate of elimination of FD-70 from serum.”

“Various solution additives affect the solubility and macroaggregation of insulin in buffered aqueous solutions at physiological pH. The solubility of insulin may be improved with the addition of small amounts of aspartic acid , glutamic acid, EDTA (ethylenediaminetetraacetic acid), lysine, Tris buffer, or bicarbonate buffer.”