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“… sedative control was significantly longer in BIS guided … first three hours [D 1, D 2 , D 3, D t: 75.2% (507) vs. 52.8% (421), D 1: 78.6% (33) vs. …) vs. 20.6% (13), D 3: 81.0% (34) vs. 31.7% (20), all P<0.01].”