“Intravenous infusion (5.5 microgram/kg/min for 30 min) of dermorphin D ) significantly increased plasma levels of prolactin (PRL), growth hormone (GH), thyrotropin (TSH) and renin activity (PRA), but decreased plasma levels of cortisol.”
“These data indicate that the action of D is mediated through opioid receptors, and are consistent with the conclusion that: (1) D, a …, perhaps via activation of the sympathetic nervous system, providing evidence that opioid peptides may exert an influence on renin secretion; (3) D … cortisol levels, by … axis.”