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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Aspartic Acid
Research Papers that Mention the Interaction
“Following the GnRH challenge, heifer calves treated with l‐NAME or NMA had higher LH pulse responses than the controls (P<0.05).”
Nitric Oxide Regulation of Gonadotrophin Secretion in Prepubertal Heifers1“Here we demonstrate that the glutamate receptor agonist, N‐methyl‐D‐aspartic acid (NMDA), nitric oxide (NO) and cGMP each repress expression of the gonadotropin‐releasing hormone (GnRH) gene in the hypothalamic cell line, GT1.”
“In addition, a significant increase in the peak LH amplitude (p less than 0.05) and the slope … amplitude (p less than 0.05) were observed for the 120 min GnRH pulse in regime C and D indicating that prior exposure …-term pulses of GnRH increased the … secretory response.”
“In mouse, rat, and monkey, N-methyl-D L-aspartic acid (NMDA) modulates gonadotropin releasing hormone (GnRH) release by an unknown mechanism.”
“Midhypothalamic GnRH concentrations were also reduced in D vs. C animals despite comparable estrogen therapy (P less than 0.004).”
“Preincubation of the pituitaries for 1 h with … antagonistic analogs [Ac Dp Cl Phe1,2, D Trp3, D Phe6, D Ala10] LHRH and [Ac Dp … Phe1,2, D Trp3, D Arg6, D Ala10] LHRH inhibited the secretion of LH and FSH induced … 2.5 x 10(-9)M LHRH.”
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