Possible Interaction: Aspartic Acid and Glycine

“There were positive correlations between plasma levels of Gly and Asp , and between Gly and Asn (P<0.005) in the control group; while in MDD patients, a significant positive correlation was found only between plasma levels of Gly and of Asp (P<0.001).”

“A single substitution of Asp with Gly in either the P3 or P'3 position of a peptide corresponding to the P7-P'5 residues of protein C increases the rate of cleavage by thrombin 2-3-fold.”

“At 0.4m-carbodi-imide reagent all of the binding of Ca(2+) to protein was abolished and it was estimated that about 37% of the side-chain carboxyl groups of aspartic acid plus glutamic acid had been blocked by glycine.”

“The apparent digestibility of alanine (P = 0.05), aspartic acid (P = 0.07), glutamic acid (P = 0.02), glycine (P = 0.05), proline (P = 0.02), and serine (P = 0.04) responded quadratically to CP content increase.”

“Substitution of the mid and proximal Asp and Glu clusters with Gly produced additive effects with respect to the induction of both bactericidal activity and membrane permeabilization of live Escherichia coli ML35 cells.”

“Concentration jump … microM NMDA in the … 10 microM glycine revealed potentiation by 3 mM spermine at a membrane potential of +60 mV, but depression at ‐120 mV; the degree … at +60 mV was variable from cell to cell while marked depression at ‐120 mV was observed in all cells.”

“The responses to Glu, NMDA, and Asp were each potentiated when 1 microM glycine was coapplied.”

“Similarly to NMDA, the effect of L-Asp was augmented by glycine and blocked by NMDA receptor antagonists, while it was insensitive to the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX).”

“In the presence of NMDA , concentration jumps from 3 microM‐glycine to lower concentrations gave relaxations which became slower with decreasing glycine concentration over the range 1 microM‐30 nM. A similar slowing of desensitization occurred when the glycine concentration was altered over the same range.”

“Adding glycine to the extracellular solution, over the range 30 nM to 3 microM, both potentiated responses to NMDA and to L‐glutamate, and reduced fast desensitization.”