Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Aspartic Acid and Glutathione

supplement:

Aspartic Acid

supplement:

Glutathione

Research Papers that Mention the Interaction

Inhibition of the GSH biosynthesis by D ,L-buthionine-R,S-sulfoximine, a specific inhibitor of gamma-glutamylcysteine synthetase, significantly reduced the glutathione conjugation of thiotepa and potentiated the cytotoxicity of thiotepa.
Cancer research  •  1998  |  View Paper
Recent reports have suggested that D ,L-buthionine-S,R-sulphoximine (BSO), a specific inhibitor of GSH synthesis, may be used to deplete tumour cell GSH and thus increase the therapeutic ratio of these agents.
British journal of cancer  •  1987  |  View Paper
Recent reports have suggested that D ,L-buthionine-S,R-sulphoximine (BSO), a specific inhibitor of GSH synthesis, may be used to deplete tumour cell GSH and thus increase the therapeutic ratio of these agents.
British Journal of Cancer  •  1987  |  View Paper
Prior depletion of glutathione by incubation of the cells for 24h with D ,L-buthionine-S,R-sulfoximine (BSO) further increased the cytotoxicity so that BSO plus *NO plus doxorubicin killed all of the clones.
Nitric oxide : biology and chemistry  •  2004  |  View Paper
Moreover, the mean GSH levels in the same esophageal tissues were significantly lower in groups C and D than in groups A and B (P < .05).
Journal of pediatric surgery  •  1999  |  View Paper
When renal glutathione was decreased to 35% of normal by pretreating rats with D ,L-buthionine-S,R-sulfoximine, the subsequent inactivation of the transpeptidase caused only a two-fold increase in arterial plasma glutathione, and urinary excretion increased to only 70% of the filtered load.
The American journal of physiology  •  1987  |  View Paper
Elevation of GSH levels in the bone marrow was inhibited with the use of D ,L-buthionine-S,R-sulfoximine (BSO), and this resulted in loss of the protective effect of CTX pre-treatment.
International journal of radiation oncology, biology, physics  •  1986  |  View Paper