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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Aspartic Acid
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“Furthermore, we showed that the combination of aspartic acid and glutamic acid exhibited enhanced antiproliferative activity, and inhibited Akt phosphorylation.”
“These results suggest that the combination of aspartic acid and glutamic acid may be useful for induction of tumor cell death, and has the potential for clinical use as a cancer therapeutic agent.”
Combination of aspartic acid and glutamic acid inhibits tumor cell proliferation.“Substitution of the glutamic acid in the EXXV sequence to aspartic acid leads to a remarkable reduction of IgE-binding ability and induces potent T cell proliferation.”
“In contrast, mutation of Glu to Asp markedly increases the affinity of NBD2 for ATP while decreasing its ability to hydrolyze ATP and to release ADP.”
“Thus, replacement of Ser by Ala, or Lys by Orn yielded completely inactive compounds and replacement of Asp by Glu decreased the activity (10(-6) M).”
“The low affinity is, at least in part, due to an Asp at position 12 of the binding loop, where mutation to Glu increases the affinity by ~4‐fold.”
“The frequency of occurrence of glutamic acid (36.90%) was higher than that of aspartic acid (27.02%).”
“Parallel studies showed that glutamic acid and aspartic acid are relatively inefficient in metal ion binding.”
“Replacement of Asp with Ala, Glu , or Asn resulted in a greater than 100-fold reduction in cleavage activity.”
“The intensity of intrinsic fluorescence of B decreased in the presence of aspartic acid and glutamic acid (Kd = 0.48 mM for aspartic acid and 0.24 mM for glutamic acid).”
“The efflux of L‐[3H]Asp and L‐[3H]Glu was inhibited in the presence of excess unlabeled L‐Asp and L‐Glu , whereas D‐Asp did not inhibit either form of efflux transport.”
Blood‐Brain Barrier Produces Significant Efflux of L‐Aspartic Acid but Not D‐Aspartic Acid
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