Possible Interaction: Aspartic Acid and Glucose

“In D compared to control subjects, the postmeal increase (∆) in glucose (1.44±2.78 vs. 0.11±0.72 mmol/l, p=0.04) and ∆nitrotyrosine (0.34±0.37 vs. -0.23±0.47 nM/l, p<0.001) were significantly higher.”

“ D and PA+D interventions had larger effects on glucose reduction than PA alone.”

“We observed 7-fold overexpression of HK2 gene in D atria with concomitant 2-fold greater activation of mitochondrial oxygen consumption by glucose , which might represent an adaption to increased energy requirements and impaired mitochondrial function by effectively joining glycolysis and oxidative phosphorylation.”

“As under this condition glucose infusion rates were lower with D than with HI (p = 0.003), it can be excluded that the cerebral effect is the consequence of a systemic effect.”

“After administration of 100 g of oral glucose , peak insulin achieved in D (60 ± 11) was lower than in IGT (101 ± 26) and ND (83 ± 20), whereas peak insulin levels in IGT and ND were significantly (P < 0.05) higher than in C (45 ± 6).”

“When islets were incubated with glucose at a high concentration (3 mg/ml), the oxygen uptake was inhibited by addition of D 860, or its metabolite, or HB 419.”

“administered 30 min before glucose load slightly reduced glucose levels and markedly increased insulin levels both in D and DC rats.”

“Both glucose and ACh induced 45Ca uptake were inhibited by D 600.”

“ D-glucose also increased the incorporation of L-leucine carbon into aspartic acid , GABA and glutamic acid suggesting stimulation of a malate shuttle mechanism.”

“It is observed that glucose in solution reduces D on the supported membrane, while having negligible effect on D on the freestanding membrane.”