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Possible Interaction: Aspartic Acid and Gentamicin


Aspartic Acid

Research Papers that Mention the Interaction

Polyaspartic acids have been reported to ameliorate the nephrotoxicity of gentamicin in vivo.
Toxicology in vitro : an international journal published in association with BIBRA  •  1993  |  View Paper
In contrast, VCs C and D significantly increased airborne Fel d 1 levels ( GM : 4.9 and 5.3 ng/m3, respectively).
Allergy  •  1998  |  View Paper
The renal toxicity of gentamicin is altered by dietary protein modifications, bicarbonate and acetazolamide administration, magnesium supplementation, polyaspartic acid , piperacillin, hypercalcemia and calcium channel blockers.
Veterinary and human toxicology  •  1990  |  View Paper
We found that in vitro polyaspartic acid (MW 9-15,000) 1) binds gentamicin with an optimum at acidic pH (5.4), 2) displaces it from negatively charged liposomes and 3) restores the activity of gentamicin-inhibited lysosomal phospholipase A1 toward phosphatidylcholine included in negatively charged liposomes.
The Journal of pharmacology and experimental therapeutics  •  1990  |  View Paper
Immunohistochemical localization studies confirmed the presence of increased amounts of gentamicin in the cytoplasm of the tubular cells of animals given gentamicin plus PAA.
PAA prevented all measured functional and pathologic evidence of gentamicin nephrotoxicity for less than or equal to 27 d of study.
Rats given PAA plus gentamicin accumulated roughly 10 times more renal aminoglycoside as did rats given gentamicin alone.
These studies demonstrate the ability of PAA to prevent experimental gentamicin nephrotoxicity.
The Journal of infectious diseases  •  1989  |  View Paper
Rats injected with gentamicin plus PAA also exhibited increased urinary excretion of alanine aminopeptidase not different in magnitude from that of rats injected with gentamicin alone, whereas N-acetyl-beta-d-glucosaminidase rose more slowly and returned to base line by day 4.
The Journal of pharmacology and experimental therapeutics  •  1989  |  View Paper
In addition to polymers of cationic amino acids (lysine, ornithine, arginine and histidine), polymers of neutral (asparagine) and acidic aspartic and glutamic acid) amino acids also exhibited inhibition of the membrane binding of gentamicin.
The Journal of pharmacology and experimental therapeutics  •  1986  |  View Paper