Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Aspartic Acid and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Neurochemical experiments revealed that the metabolism of the amino acids in the cerebral hemispheres has a tendency of increase the ratio of aspartic acid to taurin and GABA with a simultaneous enhancement of oxidation.
Georgian medical news  •  2007  |  View Paper
GABA increased the outflow of Glu (EC5017.2 μM) and Asp (EC50 18.4 μM).
Journal of neurochemistry  •  1993  |  View Paper
During simultaneous recordings from a CBT and a monosynaptically related MN, GABA applied by pressure ejection close to the CBT (Fig. 8A) completely suppressed the excitatory postsynaptic potentials (EPSPs) elicited by CBT spikes in the MN (Fig. 8, B and D).
Journal of neurophysiology  •  1992  |  View Paper
L-Aspartic acid only reduced the GABA release, whereas kainic acid exhibited only a marked enhancement of its release.
Brain Research  •  1981  |  View Paper
GABA enhanced the accumulation of amino acids (GABA, glycine, valine, proline, 5-oxoproline, serine, threonine, aspartic acid and glutamic acid) and organic acids (malic acid, lactic acid, gluconic acid, malonic acid and ribonic acid).
Physiologia plantarum  •  2017  |  View Paper
Metabolic profiling found … exogenous application of GABA led to increases in accumulations … amino acids (glutamic acid, aspartic acid , alanine, threonine, serine, and valine), organic acids (aconitic acid, malic acid, succinic acid, oxalic acid, and … acid), sugars (sucrose, fructose, glucose, galactose, and maltose), and sugar alcohols (mannitol and myo-inositol).
Scientific reports  •  2016  |  View Paper