Possible Interaction: Aspartic Acid and Gamma-Aminobutyric Acid

“Neurochemical experiments revealed that the metabolism of the amino acids in the cerebral hemispheres has a tendency of increase the ratio of aspartic acid to taurin and GABA with a simultaneous enhancement of oxidation.”

“ GABA increased the outflow of Glu (EC5017.2 μM) and Asp (EC50 18.4 μM).”

“During simultaneous recordings from a CBT and a monosynaptically related MN, GABA applied by pressure ejection close to the CBT (Fig. 8A) completely suppressed the excitatory postsynaptic potentials (EPSPs) elicited by CBT spikes in the MN (Fig. 8, B and D).”

“ L-Aspartic acid only reduced the GABA release, whereas kainic acid exhibited only a marked enhancement of its release.”

“ GABA enhanced the accumulation of amino acids (GABA, glycine, valine, proline, 5-oxoproline, serine, threonine, aspartic acid and glutamic acid) and organic acids (malic acid, lactic acid, gluconic acid, malonic acid and ribonic acid).”

“Metabolic profiling found … exogenous application of GABA led to increases in accumulations … amino acids (glutamic acid, aspartic acid , alanine, threonine, serine, and valine), organic acids (aconitic acid, malic acid, succinic acid, oxalic acid, and … acid), sugars (sucrose, fructose, glucose, galactose, and maltose), and sugar alcohols (mannitol and myo-inositol).”