Possible Interaction: Aspartic Acid and Cysteine

“High or abuse concentrations of ASP hydrolysis products significantly decreased the membrane enzyme activity, which was completely or partially prevented by L-cysteine or reduced GSH.”

“The addition of an aqueous solution (20 μL) of cysteine or aspartic acid …-NP dispersion causes no aggregation, while the addition of an aqueous solution of cysteine into … aspartic acid (1.8 mM) causes the aggregation of Au-NPs and … change of the colloid from wine red to blue.”

“These changes are ascribed to the ion pair interaction between aspartic acid and cysteine on the interface between Au-NPs and solution.”

“The sensitizing effects of L-cysteine in wild-type mice were inhibited by a cystathionine β-synthase inhibitor, D ,L-propargylglycine (PAG), which inhibits H2S formation.”

“Mg2+-ATPase activity was not affected by STZ-induced diabetes, while Cys caused a significant inhibition of the enzyme, both in vivo (−14%, C + Cys vs CB;−17%, D + Cys vs CB) and in vitro (−16%, DB + in vitro Cys vs CB).”

“It was found that the D -isomers of penicillamine and cysteine are better inhibitors of the decarboxylase activity than the L -isomers.”

“When this Cys is mutated to Asp , the enzymatic activity increases 10-fold.”

“The inhibitory effect of cystein was reversed by pantothenic acid, beta-alanine, aspartate and aspartic acid.”