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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Aspartic Acid
drug:
Clonidine
Research Papers that Mention the Interaction
“When leukocytes were incubated simultaneously with D 4026 and a histamine H-2 receptorstimulating drug (histamine or clonidine ), the two drugs combined induced an inhibition significantly greater than the sum of their individual inhibitory effects.”
Inhibition of IgE-mediated histamine release from human leukocytes by a new xanthine derivative, D 4026“When clonidine (10(-4) M) was added to the perfusion medium, the K(+)-evoked overflow of both Asp and Glu was inhibited by 50-90% in the anterior cortex, thalamus and hypothalamus.”
Presynaptic inhibition by clonidine of neurotransmitter amino acid release in various brain regions.“ Clonidine inhibited K(+)-evoked Glu and Asp overflow to 40 and 30% of the control with a potency (IC50) of 11 and 36 nM, respectively.”
“ Clonidine inhibited the K(+)-evoked overflow of Glu and Asp in a concentration-dependent manner, but the GABA overflow was not inhibited.”
“D inhibited the contraction evoked by KC1 40 mmol/L in rabbit … IC50 value of 93 Umol/L. The dase-response curve for clonidine to inhibit electrical stimulation-evoked contraction of the … rat vas deferens was shifted rightward parallejly by D 30, 100 vmol/L … value of 5.1.”
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