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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Aspartic Acid and 8-Chloro-Cyclic Adenosine Monophosphate

Research Papers that Mention the Interaction

The phosphodiesterase (PDE) is a super family represented by four genes: PDE4A, B,C, and D causes the hydrolysis of phosphodiester bond of cAMP to yield inactive AMP.
Current computer-aided drug design  •  2018  |  View Paper
The F alpha-helix, which provides all base-specific contacts in the CRP-DNA complex, became hypersensitive to Fe-EDTA-mediated cleavage, whereas the solvent exposure of D and E alpha-helices was decreased upon binding of cAMP.
Biochemistry  •  1997  |  View Paper
We find that lipolytic cleavage of the two membrane anchors by phosphatidylinositol-specific phospholipases C and D results in significantly higher association and lower dissociation rates of cAMP , thus leading to a dramatic increase in ligand affinity of the two cAMP receptors.
Archives of biochemistry and biophysics  •  1994  |  View Paper
Mutating these same residues to aspartic acid , mimicking PKA phosphorylation, leads to a decrease in G(s)-stimulated cAMP accumulation and an increase in PTX-sensitive ERK activation.
Cellular signalling  •  2004  |  View Paper