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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aspartate
supplement:
Magnesium Cation
Research Papers that Mention the Interaction
“Mutants of Asp133 suggest that the magnesium ion interacts with both Pi and the aspartate side chain and plays a role in positioning Pi and NAD.”
Magnesium and Phosphate Ions Enable NAD Binding to Methylenetetrahydrofolate Dehydrogenase-Methenyltetrahydrofolate Cyclohydrolase*“Perfusion of the N‐methyl‐D‐aspartate (NMDA) receptor channel blockers, dizocilpine (MK‐801; 75 μM) and Mg2+ (2.5 mM), inhibited the ischaemia‐induced accumulation of glutamate and aspartate.”
Blockers of NMDA‐operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats“Iontophoretic application of magnesium ions selectively antagonized responses to N-methyl-D, L-aspartate but did not convert the repetitive firing pattern into a burst firing pattern.”
“Phencyclidine (PCP) and … concentrations of Mg++ (1.2 mM) also inhibited ACh release evoked by L-glutamate, L-aspartate and DL-homocysteate, but not ACh release evoked by the glutamate analogs quisqualate and kainate, suggesting that PCP is selective for the magnesium-sensitive, NMDA-preferring glutamate-aspartate receptor subtype.”
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