Possible Interaction: Aspartate and Calcium Supplement

“One problem associated with the E59D whole protein variant is a prohibitively close approach of the aspartate carboxyl group to the CD calcium ion observed in the energy-minimized (pre-molecular dynamics) structure.”

“At 2 mM or lower [phosphate] in the medium, calcium inhibited glutamine utilization and the production of glutamate, aspartate , and ammonia from glutamine.”

“These results suggest that calcium ions enhance the effect of glutamate and aspartate in immature neurons, possibly by interacting with the ionophores involved in amino acid responses.”

“Iontophoretic application of glutamate or aspartate caused dose-dependent delta Ca of more than 1 mM and delta Na of more than 45 mM. Such ionic alterations were smaller in the presence of GABA or of the Ca2+ antagonists Ni2+ and Mg2+.”

“Iontophoretic applications of the excitatory amino acids glutamate, aspartate and DL-homocysteate evoked delta Ca by up to 1.2 mM. delta Ca were largest at a depth of 100-300 micron below cortical surface.”

“The amino acids, d,l -homocysteate (DLH), glutamate, and aspartate , which excite virtually all other central neurons, often inhibited mitral cells and this effect was blocked by Mg 2+ .”

“The metabolome of fruit exposed to calcium also displayed substantial modulations, particularly in the levels of galactose, glycerate, aspartate , tryptophan, phospharate rutin, and peonidin 3-O-glucoside.”