Possible Interaction: Aspartame and Serum Albumin, Human

“Combining above results and those of spectrofluorometric competition experiment and circular dichroism (CD), indicated that APM … Sudlow’s site I. Furthermore, the study of molecular docking on HSA binding also indicated that APM can strongly bind … (subdomain IIA) of HSA mainly by hydrophobic interaction and … between APM and HSA.”

“The results indicated that the binding of APM to HSA caused fluorescence quenching of HSA through static quenching mechanism with binding constant 1.42 × 10+4 M−1 at 298 K and the number of binding sites is approximately one.”