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Last Updated: 2 years ago

Possible Interaction: Aspartame and Phenylalanine

supplement:

Phenylalanine

Research Papers that Mention the Interaction

Aspartame L-aspartyl-L-phenylalanine methyl ester ) consumption has been postulated to increase brain phenylalanine levels by increasing the molar ratio of the plasma phenylalanine concentration to the sum of the plasma concentrations of the other large neutral amino acids (Phe/LNAA).
Pharmacology  •  1991  |  View Paper
The addition of APM to the beverage did not significantly increase plasma aspartate concentration but did increase plasma phenylalanine levels 2.3 to 4.1 mumol/dL above baseline values 30 to 45 min after each dose.
The high mean plasma phenylalanine concentration and the phenylalanine to large neutral amino acid ratio were significantly higher when APM was ingested as a single bolus than when ingested as a divided dose.
The high mean plasma phenylalanine level after repeated APM dosing (13.9 +/- 2.15 mumol/dL) was slightly, but not significantly, above the normal postprandial range for PKUH (12.6 +/- 2.11 mumol/dL).
Metabolism: clinical and experimental  •  1989  |  View Paper
APM addition did increase plasma phenylalanine levels 1.64 to 2.05 mumol/dL above baseline values (5.09 +/- 0.82 mumol/dL) 30 to 45 minutes after each dose.
Metabolism: clinical and experimental  •  1988  |  View Paper
APM … phenylalanine levels of normal subjects from a mean +/- SD baseline value of 5.09 +/- 0.82 mumol/dL to a high mean value of 6.… metabolism of the aspartate and phenylalanine portion of APM when administered at levels likely to be ingested by individuals who drink diet beverages.
The Journal of nutrition  •  1987  |  View Paper
Compared with the meal alone, ingestion of the meal plus APM significantly increased plasma Phe concentrations in both controls and PKU heterozygotes.
Metabolism: clinical and experimental  •  1994  |  View Paper
It has been suggested that excessive use of APM might elevate plasma aspartate, phenylalanine , and/or methanol concentrations to levels that are potentially harmful.
Metabolism: clinical and experimental  •  1989  |  View Paper
Two days later, oral aspartame (APM; aspartylphenylalanine methylester) administration substantially increased serum phenylalanine (Phe) concentrations and the ratio, in serum, of Phe to the sum of its competitors for transport into brain and retina (the other large neutral amino acids).
The American journal of clinical nutrition  •  1991  |  View Paper
Administration of the artificial sweetener aspartame L-aspartylphenylalanylmethyl ester ; 200 mg/kg) by gavage to rats caused large increments in brain and plasma levels of phenylalanine and its product tyrosine.
The American journal of clinical nutrition  •  1984  |  View Paper