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Possible Interaction: Aspartame and Phenylalanine



Research Papers that Mention the Interaction

Mean plasma phenylalanine (Phe) concentrations increased significantly after aspartame ingestion (83.6 microM) as compared with placebo (52.3 microM).
Epilepsia  •  1995  |  View Paper
Plasma phenylalanine significantly increased, within the normal range for PKUH, at 1 and 3 h following the morning dose of aspartame in the group receiving the 45 mg/kg per day dose only.
Human Genetics  •  1994  |  View Paper
Aspartame (L-aspartyl-L-phenylalanine methyl ester) consumption has been postulated to increase brain phenylalanine levels by increasing the molar ratio of the plasma phenylalanine concentration to the sum of the plasma concentrations of the other large neutral amino acids (Phe/LNAA).
Pharmacology  •  1991  |  View Paper
Plasma phenylalanine levels were significantly higher following aspartame (P less than .01) than with placebo between 1 and 6 hours postdosage, reaching a maximum difference of +3.36 mumols/dl at 2 hours.
Journal of clinical pharmacology  •  1990  |  View Paper
The high mean plasma phenylalanine concentration and the phenylalanine to large neutral amino acid ratio were significantly higher when APM was ingested as a single bolus than when ingested as a divided dose.
Metabolism: clinical and experimental  •  1989  |  View Paper
APM ingestion increased plasma phenylalanine levels of normal subjects from a mean +/- SD baseline value of 5.09 +/- 0.82 mumol/dL to a high mean value of 6.73 +/-
APM … phenylalanine levels of normal subjects from a mean +/- SD baseline value of 5.09 +/- 0.82 mumol/dL to a high mean value of 6.… metabolism of the aspartate and phenylalanine portion of APM when administered at levels likely to be ingested by individuals who drink diet beverages.
The Journal of nutrition  •  1987  |  View Paper
The area under the four-hour plasma phenylalanine concentration-time curve was significantly higher (15,340 +/- 4,820 v 8,465 +/- 3,356 mumol/L X min) when aspartame was ingested in solution.
Metabolism: clinical and experimental  •  1987  |  View Paper
It has been suggested that excessive use of APM might elevate plasma aspartate, phenylalanine , and/or methanol concentrations to levels that are potentially harmful.
Metabolism: clinical and experimental  •  1989  |  View Paper
However, aspartame addition did significantly increase the mean plasma phenylalanine concentration above values noted after ingestion of the meal alone or the meal with added MSG, reflecting aspartame's phenylalanine content.
The Journal of nutrition  •  1983  |  View Paper
The consumption of aspartame , unlike dietary protein, can elevate the levels of phenylalanine and aspartic acid in the brain.
Nutritional neuroscience  •  2017  |  View Paper
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