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Discover Supplement-Drug Interactions

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Last Updated: 24 days ago

Possible Interaction: Asparagine and Tiotropium

supplement:

Asparagine

Research Papers that Mention the Interaction

The exceedingly long half-life of tiotropium (of more than 24 h) is attributed to interactions in the binding site; particularly a highly directed interaction of the ligands' hydroxy group with an asparagine (N508(6.52)) prevents rapid dissociation via a snap-lock mechanism.
Journal of medicinal chemistry  •  2013  |  View Paper