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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Asparagine
drug:
Tiotropium
Research Papers that Mention the Interaction
“The exceedingly long half-life of tiotropium (of more than 24 h) is attributed to interactions in the binding site; particularly a highly directed interaction of the ligands' hydroxy group with an asparagine (N508(6.52)) prevents rapid dissociation via a snap-lock mechanism.”
Molecular basis for the long duration of action and kinetic selectivity of tiotropium for the muscarinic M3 receptor.
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