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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Asparagine
supplement:
Threonine
Research Papers that Mention the Interaction
“Replacement of threonine with asparagine decreases the activity of carbamoyl phosphate synthase in the urea cycle.”
Perioperative exacerbation of valproic acid-associated hyperammonemia: a clinical and genetic analysis.“Substitution of Thr with Asn in the TAA motif of FgAQP-1 increased its water permeability twofold but did not affect urea and glycerol impermeability while the substitution at the pore mouth of Cys204 by Tyr caused loss of water permeability.”
Functional analysis of novel aquaporins from Fasciola gigantica.“Both the distance between Thr and Asn and the ordering of the two residues are crucial for effective ice binding.”
“Substitution of Cys at position 39 blocks glycosylation, whereas substitution of Thr dramatically increases core glycosylation efficiency of Asn in both membrane-anchored and secreted forms of RGP.”
“Site-directed mutagenesis experiments showed that replacement of Asn by Thr decreased both the catalytic efficiency and the binding affinity by 2.3- and 7.0-fold, respectively, and substitution of Leu73 for Ala predominantly decreased the binding affinity by 14.”
Crystal structures of the ribonuclease MC1 from bitter gourd seeds, complexed with 2'-UMP or 3'-UMP, reveal structural basis for uridine specificity.“Replacement of Asn by residues with shorter side chains resulted in either a small loss (Ala) or gain ( Thr ) of antifreeze activity.”
“All other amino acids with the exception of histidine, arginine, asparagine , and hydroxyproline inhibited threonine uptake.”
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