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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Asparagine
supplement:
Serine
Research Papers that Mention the Interaction
“All mutants exhibited similar plasma membrane expression when compared with WT SLC1A2, but substitutions of serine by aspartate or asparagine completely abolished substrate transport.”
The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2*“Mutation of serine to other amino acids with varying side chains: alanine, methionine, leucine, aspartic acid, asparagine , and arginine also resulted in significant activation, indicating a serine-specific inhibitory effect.”
“Substitution of asparagine for serine at position 17 of human H-ras results in an impaired GTP-binding activity, causing the mutant Ras protein to be locked in a constitutively inactive GDP-bound state.”
“Substitution of an asparagine residue at position 102 by serine (N102S), the residue found in the analogous position of the mouse and rat min K proteins, results in decreased gpIsK in response to PKC stimulation.”
“Mutagenesis of the serine residue at position 529, the putative aspirin acetylation site, to an asparagine reduced cyclooxygenase activity to barely detectable levels, an effect observed previously with the expressed sheep vesicular gland enzyme.”
“Through asparagine synthetase knockdown and altering of media asparagine concentrations, we show that intracellular asparagine levels regulate uptake of amino acids, especially serine , arginine and histidine.”
“Mutation of an asparagine to a serine residue at position 290 dramatically reduced both etomidate-induced chloride currents and its ability to enhance [3H]flunitrazepam binding in HEK293 cells expressing alpha1beta3gamma2 recombinant GABA(A) receptors.”
“Replacement of the Ser at position 17 by Asn severely impairs the GTP binding ability of the protein and points to an important role of this residue in the coordination of Mg2+.”
“Under water stress asparagine , phenylalanine, serine , and histidine also declined compared to controls.”
Changes in free amino acids and polyamine levels in Satsuma leaves in response to Asian citrus psyllid infestation and water stress“A detailed analysis revealed multiple sites for asparagine were being randomly substituted by serine , pointing to mistranslation as the likely source.”
“Reduction in serine concentration under asparagine starvation conditions helped reduce extent of misincorporation.”
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