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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Asparagine and Penicillins

supplement:

Asparagine

Research Papers that Mention the Interaction

Studies exploring the YXN loop asparagine in the Escherichia coli AmpC, P99, and CMY-2 enzymes have suggested that interactions between C6′ or C7′ substituents on penicillins or cephalosporins and this Asn are important in determining substrate specificity and enzymatic stability.
Antimicrobial Agents and Chemotherapy  •  2014  |  View Paper
Insertion of other amino acids, including Glu and Asn , can also lower the rate of acylation by penicillin , but these insertions abolish transpeptidase function.
Biochemistry  •  2014  |  View Paper
Replacement of His99 with Asn (H99N) significantly reduced the hydrolytic activity for penicillin and imipenem.
The Journal of Biological Chemistry  •  1999  |  View Paper
Casein hydrolysate, asparagine , glutamic acid to a lesser degree, and possibly some other aminoacids partially antagonize the effect of penicillin upon E. coli in synthetic medium.
Science  •  1945  |  View Paper