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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Asparagine
drug:
Penicillins
Research Papers that Mention the Interaction
“Studies exploring the YXN loop asparagine in the Escherichia coli AmpC, P99, and CMY-2 enzymes have suggested that interactions between C6′ or C7′ substituents on penicillins or cephalosporins and this Asn are important in determining substrate specificity and enzymatic stability.”
Effect of Asparagine Substitutions in the YXN Loop of a Class C β-Lactamase of Acinetobacter baumannii on Substrate and Inhibitor Kinetics“Insertion of other amino acids, including Glu and Asn , can also lower the rate of acylation by penicillin , but these insertions abolish transpeptidase function.”
“Replacement of His99 with Asn (H99N) significantly reduced the hydrolytic activity for penicillin and imipenem.”
“Casein hydrolysate, asparagine , glutamic acid to a lesser degree, and possibly some other aminoacids partially antagonize the effect of penicillin upon E. coli in synthetic medium.”
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