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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Asparagine
supplement:
NAD
Research Papers that Mention the Interaction
“Substitutions of Glu-267 with histidine or asparagine residues increase the dissociation constants for the coenzymes ( NAD+ by ∼40-fold, NADH by ∼200-fold) and significantly decrease catalytic efficiencies by 16-1200-fold various substrates and substituted enzymes.”
Substitutions of a buried glutamate residue hinder the conformational change in horse liver alcohol dehydrogenase and yield a surprising complex with endogenous 3'-Dephosphocoenzyme A.“The asparagine mutant was approximately 50-fold-attenuated in NAD glycohydrolase activity, however.”
Active-site mutations of the diphtheria toxin catalytic domain: role of histidine-21 in nicotinamide adenine dinucleotide binding and ADP-ribosylation of elongation factor 2.
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