Possible Interaction: Asparagine and Leucine

“Glutamine, asparagine , histidine, alanine, and leucine showed mutual inhibition of transport.”

“Moreover, enhancements of hydrophobicity following substitution of AmyI‐1‐18 asparagine with leucine led to greater increases in cell migration.”

“Combinations of leucine (0.5 mM) with either alanine, glutamine, asparagine or proline (2 mM) inhibited proteolysis by 40-50%.”

“It is proposed that the enhancing action of L-asparagine upon insulin release evoked by L-leucine is attributable to an increased generation rate of cytosolic NADPH rather than any increase in nutrients oxidation.”

“The association of L-asparagine and L-leucine exerted a sparing action on the utilization of endogenous amino acids, so that the integrated rate of nutrients oxidation was virtually identical in the sole presence of L-leucine and simultaneous presence of L-asparagine and L-leucine, respectively.”

“It is proposed that the enhancing action of L-asparagine upon insulin release evoked by L-leucine might be due to an accelerated generation rate of cytosolic NAOPH, rather than to any sizable increase in either islet respiration or steady-state cytosolic NADPH/NADP+ ratio.”

“The secretory response to the combination of L-asparagine and L-leucine was augmented by theophylline and inhibited in the absence of extracellular Ca2+ or presence of either menadione or methylamine.”

“Replacement with the corresponding leucine from ASPGA1 specifically lowered the Vmax value with Asn as substrate by 8.4-fold.”