Possible Interaction: Asparagine and Insulin

“Classical autophagy inhibitors including 3-methyladenine, L-asparagine and bafilomycin A1 also blocked the ability of insulin to suppress apo B secretion by rat hepatocytes (RH) suggesting that IDAD occurs through an autophagy-related mechanism.”

“Net negative balances of alanine, methionine, glycine, threonine and asparagine (typical substrates for system A amino acid transport) also were decreased by insulin , whereas serine (another substrate for system A transport) shifted from a zero balance to net uptake.”

“The stimulatory effect of partially hydrolyzed insulin , used as a source of strepogenin, was considerably enhanced by the presence of an excess of asparagine , the effect being greater than the sum of the responses to the individual substances.”

“Other factors like dibutyryl cyclic AMP and insulin also potentiated the effects of asparagine on ODC activity.”

“Continuous intravenous infusion of glutamine (3 mmol/… estimated fetal weight) or glutamine and asparagine each at this rate for 2 h into chronically cannulated fetal … utero significantly increased plasma glucagon (P less than 0.05) and insulin (P less than 0.01) concentrations, … effect on glucagon was not great.”