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Last Updated: 3 months ago

Possible Interaction: Asparagine and Aspartic Acid

supplement:

Asparagine

supplement:

Aspartic Acid

Research Papers that Mention the Interaction

Concentrations of aspartic acid increased in parallel with ASN degradation.
Therapeutic drug monitoring  •  2014  |  View Paper
Both N and D synergistically augmented T-mediated S-phase depletion, and they also effectively reduced colonies, which were more potent by N by 49%.
Surgical neurology  •  2006  |  View Paper
Exchange of aspartic acid at position 286 or 288 with alanine or asparagine decreased glucosyltransferase activity by about 5000-fold and completely blocked glucohydrolase activity.
The Journal of biological chemistry  •  1998  |  View Paper
Asparagine stimulated pathogen growth; conversely, amended medium with aspartic acid significantly inhibited the conidia germination and mycelial development of M. laxa.
International journal of food microbiology  •  2017  |  View Paper
An exchange of the aspartic acid residue at the cleavage site with asparagine prevented cleavage; however, cleavage was still observed with glutamic acid at the same position, indicating that a negative charge at the cleavage site is sufficient.
Journal of bacteriology  •  2011  |  View Paper
Pretreatment with glutamic and aspartic acids was more inhibitory (70-80%) than with glutamine and asparagine (30%).
Plant science : an international journal of experimental plant biology  •  2001  |  View Paper
Arginine methyl ester (99.5 and 97% inhibition), argininamide (99 and 96%), S-(2-aminoethyl) cysteine (43 and …%), aspartic acid beta-methyl ester (38 and 40%), norvaline (0 and 3%), citrulline (9 and 7%), and asparagine (2 and 0%) exhibited … of both arginine and aspartic acid , respectively, when … mixture.
Applied and environmental microbiology  •  2001  |  View Paper
By making site-directed mutations at these positions and analysing the … vivo and to resolve junctions in vitro, we identified three aspartic acid residues (D70, D72 and D91) that are essential for catalysis and that provide … resolution by RusA. Substitution of any one of these three residues with asparagine ….
Journal of molecular biology  •  1999  |  View Paper
In sharp contrast, when aspartic acid or alanine was substituted for asparagine-44 , the activity was dramatically reduced to a few percent of the wild-type activity.
Proceedings of the National Academy of Sciences of the United States of America  •  1986  |  View Paper
Kinetic studies also revealed that L-aspartic acid inhibited L-asparaginase competitively, with an inhibition constant of 80 microM at micromolar concentrations of L-asparagine ; at millimolar concentrations of the amide, an increase in maximal velocity but a decrease in affinity for L-asparagine were observed.
Journal of enzyme inhibition  •  1986  |  View Paper
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