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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Asparagine and Aspartic Acid

supplement:

Asparagine

supplement:

Aspartic Acid

Research Papers that Mention the Interaction

Substitution of an aspartic acid residue at position 62 in an asparagine residue within a putative caspase cleavage site completely blocked cleavage of CaMKLK, strongly indicating that59DEND62 is the caspase recognition site.
The Journal of Biological Chemistry  •  2001  |  View Paper
However, acid solutions of insulin are chemically unstable as A21 asparagine both deamidates to aspartic acid and takes part in formation of covalent dimers via alpha-amino groups of other molecules.
Protein engineering  •  1988  |  View Paper
Concentrations of aspartic acid increased in parallel with ASN degradation.
Therapeutic drug monitoring  •  2014  |  View Paper
The difference in velocity between Asn and Asp isomerization is approximately 50-fold.
Amino Acids  •  2012  |  View Paper
Exchange of aspartic acid at position 286 or 288 with alanine or asparagine decreased glucosyltransferase activity by about 5000-fold and completely blocked glucohydrolase activity.
The Journal of Biological Chemistry  •  1998  |  View Paper
Replacement of Asp with Ala, Glu, or Asn resulted in a greater than 100-fold reduction in cleavage activity.
Journal of immunology  •  1991  |  View Paper
Whereas the folding of the mutated proteins was not seriously disrupted as judged by assembly into …, Golgi localization, and secretion of a soluble form of the enzyme, exchange of the highly conserved aspartic acid residues at position 356 or … with alanine or asparagine reduced enzyme activity to background levels.
Glycobiology  •  2001  |  View Paper
Substitution of asparagine for the highly conserved aspartic acid at position 118 resulted in a complete loss of all three activities, confirming that the catalytic domain resides in the central core region (residues 53-188) of the protein.
Virology  •  1997  |  View Paper
They found that the Asp to Asn mutation has only a small effect on the binding; the observed differences in the free energies on changing one Asp to an Asn are between -0.3 and 1.8 kcal/mol.
Protein engineering  •  1993  |  View Paper
6 Substitution of Asp by Asn in position 7 of dermenkephalin caused an increase in μ‐receptor potency and a decrease in δ‐receptor potency, resulting in a 20 fold decrease in μ‐receptor selectivity.
British journal of pharmacology  •  1991  |  View Paper
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