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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Asparagine and 8-Chloro-Cyclic Adenosine Monophosphate

Research Papers that Mention the Interaction

When dibutyryl cAMP was added with asparagine , a 40–50 fold stimulation of ornithine decarboxylase activity was produced.
Biochemical and biophysical research communications  •  1978  |  View Paper
Glutamine elevated intracellular cAMP to 36% of that produced by a maximal stimulus, whereas asparagine only increased intracellular cAMP by 24% and phenylalanine was without effect.
Endocrinology  •  2011  |  View Paper
Addition … dB cAMP at various times after placing … in salts/glucose medium with ASN further stimulated ODC activity only when added during the first 3-4 h. These results demonstrate the involvement … cAMP in the ASN mediated stimulation of ODC activity using cells maintained in a salts/glucose medium.
Other agents which elevated cAMP levels such as 1-methyl-3-isobutylxanthine (IBMX) also enhanced ODC activity when administered with ASN.
The synergistic stimulation of ODC activity by dB cAMP added with ASN was dose dependent and the dB cAMP stimulation of ODC activity displayed an absolute requirement for ASN when cells were maintained in the salts/glucose medium.
cAMP (dB … the ASN caused up to a 50 fold increase in the activity of this enzyme after 7--8 h. The enhancement of ODC activity by … was not sensitive to continuous (0--7 h) treatment with actinomycin D but similar treatment with cycloheximide depressed enzyme activity 40--60%.
Journal of cyclic nucleotide research  •  1978  |  View Paper