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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Asparaginase
supplement:
Trypsin
Research Papers that Mention the Interaction
“ConclusionsLevels of serum trypsin and PSTI were elevated during the 2 weeks after administration of ASNase , which suggested the presence of subclinical pancreatitis.”
L-Asparaginase-Induced Pancreatic Injury is Associated with an Imbalance in Plasma Amino Acid Levels“However, the serum trypsin and elastase-1 levels, 10 and 20 days after beginning L-asparaginase therapy , were significantly higher than those prior to therapy.”
“ Trypsin digestion can induce artificial modifications such as asparagine deamidation and N-terminal glutamine cyclization on proteins due to the temperature and the alkaline pH buffers used during digestion.”
An improved trypsin digestion method minimizes digestion-induced modifications on proteins.
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