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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Asparaginase
supplement:
Glucose
Research Papers that Mention the Interaction
“A variable pattern of insulin response to glucose has been reported in patients treated with L-ASP.”
Study of β‐cell Function and Erythrocyte Insulin Receptors in a Patient with Diabetic Ketoacidosis Associated with L‐asparaginase Therapy“The addition of glucose or ammonium ion to the medium, however, resulted in depressed production of l-asparaginase.”
L-Asparaginase from Proteus vulgaris.“Compared to no carbohydrate supplemented medium, glucose caused a slight repression of L‐asparaginase in P. aeruginosa, while it stimulated it in the PaJC strain.”
Effect of Vitreoscilla hemoglobin on production of a chemotherapeutic enzyme, L‐asparaginase, by Pseudomonas aeruginosa“Apparently, a decrease in the intracellular content of cAMP caused by glucose could not be the only factor inhibiting L-asparaginase synthesis.”
“The inhibition of L-asparaginase synthesis by glucose seems to be due, at least partly, to the fact that it prevents the assimilation of lactate by the cells, as well as the utilization of some other compounds which stimulate synthesis of this enzyme.”
“The addition of glucose to the medium, however, resulted in depressed production of l-asparaginase.”
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