Possible Interaction: Asparaginase and Asparagine

“There was correlation between asparaginase enzymatic activity and depletion of asparagine or glutamine in serum.”

“ L-asparaginase catalyses the hydrolysis of L-asparagine to aspartic acid and ammonia3.”

“CONCLUSIONS AND CLINICAL IMPORTANCE L- sparaginase si gnificantly reduced asp aragine co ncentrations within 2 days of treatment, but this effect was lost within 7 days.”

“The removal of asparagine by l‐asparaginase leads to the reduction of acrylamide formation in fried food items.”

“ ASNase primarily depletes circulating asparagine , and the endogenously expressed enzyme, asparagine synthetase (ASNS), replenishes asparagine.”

“Decreases in plasma asparagine levels due to the administration of l-asparaginase were closely related to the dosing time-dependency of its anti-tumor effects.”

“Actually, l-asparaginase catalyzes the hydrolysis of l-asparagine , not allowing the reaction of reducing sugars with this aminoacid for the generation of acrylamide.”

“Notably, treatment with L-asparaginase elicited both specific diricore signals at asparagine codons and high levels of asparagine synthetase (ASNS).”

“The enzyme colaspase (L-asparaginase) acts to limit the supply of L-asparagine to tissues unable to synthesise this amino acid, while the vinca alkaloids (vinblastine and vincristine) produce metaphase arrest probably by specific interaction with microtubular protein, a component of the spindle apparatus.”

“Addition of D-asparagine , a competitive inhibitor of T. pyriformis L-asparaginase, counteracts the antiproliferative activity of L-asparaginase , indicating that L-asparaginase and not the kinase activity is responsible for that effect.”