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Last Updated: 4 months ago

Possible Interaction: Asparaginase and Asparagine

supplement:

Asparagine

Research Papers that Mention the Interaction

L-asparaginase catalyses the hydrolysis of L-asparagine to aspartic acid and ammonia3.
Australian and New Zealand journal of medicine  •  1971  |  View Paper
l-asparaginase is an anti-cancer enzyme that deprives the cancer cells of l-asparagine.
l-asparagine deprivation by l-asparaginase induced metabolic stress, cytotoxicity and apoptosis by G0 phase cell-cycle arrest, modulated the mitochondrial membrane integrity, accelerated caspase-3 activation and instigated DNA damage.
Biochemical and biophysical research communications  •  2018  |  View Paper
Asparagine deprivation by L-asparaginase exacerbated growth inhibition induced by glutamine starvation and autophagy blockage.
Oncotarget  •  2017  |  View Paper
l-Asparaginase is an antineoplastic agent that selectively reduces the level of l-asparagine in blood and diminishes the proliferation of cancerous cells.
Gene  •  2016  |  View Paper
We demonstrated that deprivation of asparagine by asparaginase could induce significant cytotoxicity and apoptosis in A549 and H1975 cells.
Applied Microbiology and Biotechnology  •  2016  |  View Paper
Asparaginase , an enzyme used to treat acute lymphoblastic leukemia and related forms of nonHodgkin lymphoma, depletes asparagine , which leads to lymphoblast cell death.
Pediatric blood & cancer  •  2015  |  View Paper
In an additional analysis for the role of asparagine …, ATRA-mediated HL-60 cell differentiation was enhanced when asparagine in the culture media was … by an addition of L-asparaginase , indicating that downregulation of asparagine synthetase gene expression may be involved in the enhanced cell differentiation by STL compounds.
International journal of oncology  •  2014  |  View Paper
Asparaginases catalyze the hydrolysis of the amino acid asparagine to aspartate and ammonia.
The key property allowing for the depletion of blood asparagine by bacterial asparaginases is their low micromolar KM value.
Journal of molecular biology  •  2014  |  View Paper
l-asparaginase is an aminohydrolase that deprives leukemia cells of l-asparagine required for protein synthesis.
Pharmacotherapy  •  2014  |  View Paper
In addition the use of fibrinogen concentrate as an alternative to FFP would avoid both the risk of TRALI and especially the exposure of the patient to a source of asparagine which could counteract the antineoplastic action of asparaginase.
In addition the use of fibrinogen concentrate as an alternative to FFP would avoid both the risk of TRALI and especially the exposure of the patient to a source of asparagine which could counteract the antineoplastic action of asparaginase.
Blood transfusion = Trasfusione del sangue  •  2014  |  View Paper
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